%0 Journal Article
%T A Role for Methyl-CpG Binding Domain Protein 2 in the Modulation of the Estrogen Response of pS2/TFF1 Gene
%A Amandine Chatagnon
%A Esteban Ballestar
%A Manel Esteller
%A Robert Dante
%J PLOS ONE
%D 2012
%I Public Library of Science (PLoS)
%R 10.1371/journal.pone.0009665
%X In human Estrogen Receptor ¦Á (ER¦Á)-positive breast cancers, 5¡ä end dense methylation of the estrogen-regulated pS2/TFF1 gene correlates with its transcriptional inhibition. However, in some ER¦Á-rich biopsies, pS2 expression is observed despite the methylation of its TATA-box region. Herein, we investigated the methylation-dependent mechanism of pS2 regulation.
%U http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0009665