%0 Journal Article %T NADPH Oxidase Limits Innate Immune Responses in the Lungs in Mice %A Brahm H. Segal %A Wei Han %A Jennifer J. Bushey %A Myungsoo Joo %A Zahida Bhatti %A Joy Feminella %A Carly G. Dennis %A R. Robert Vethanayagam %A Fiona E. Yull %A Maegan Capitano %A Paul K. Wallace %A Hans Minderman %A John W. Christman %A Michael B. Sporn %A Jefferson Chan %A Donald C. Vinh %A Steven M. Holland %A Luigina R. Romani %A Sarah L. Gaffen %A Michael L. Freeman %A Timothy S. Blackwell %J PLOS ONE %D 2012 %I Public Library of Science (PLoS) %R 10.1371/journal.pone.0009631 %X Chronic granulomatous disease (CGD), an inherited disorder of the NADPH oxidase in which phagocytes are defective in generating superoxide anion and downstream reactive oxidant intermediates (ROIs), is characterized by recurrent bacterial and fungal infections and by excessive inflammation (e.g., inflammatory bowel disease). The mechanisms by which NADPH oxidase regulates inflammation are not well understood. %U http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0009631