%0 Journal Article
%T New Sequence Variants in HLA Class II/III Region Associated with Susceptibility to Knee Osteoarthritis Identified by Genome-Wide Association Study
%A Masahiro Nakajima
%A Atsushi Takahashi
%A Ikuyo Kou
%A Cristina Rodriguez-Fontenla
%A Juan J. Gomez-Reino
%A Tatsuya Furuichi
%A Jin Dai
%A Akihiro Sudo
%A Atsumasa Uchida
%A Naoshi Fukui
%A Michiaki Kubo
%A Naoyuki Kamatani
%A Tatsuhiko Tsunoda
%A Konstantinos N. Malizos
%A Aspasia Tsezou
%A Antonio Gonzalez
%A Yusuke Nakamura
%A Shiro Ikegawa
%J PLOS ONE
%D 2012
%I Public Library of Science (PLoS)
%R 10.1371/journal.pone.0009723
%X Osteoarthritis (OA) is a common disease that has a definite genetic component. Only a few OA susceptibility genes that have definite functional evidence and replication of association have been reported, however. Through a genome-wide association study and a replication using a total of ~4,800 Japanese subjects, we identified two single nucleotide polymorphisms (SNPs) (rs7775228 and rs10947262) associated with susceptibility to knee OA. The two SNPs were in a region containing HLA class II/III genes and their association reached genome-wide significance (combined P = 2.43¡Á10£¿8 for rs7775228 and 6.73¡Á10£¿8 for rs10947262). Our results suggest that immunologic mechanism is implicated in the etiology of OA.
%U http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0009723