%0 Journal Article
%T Principles and Determinants of G-Protein Coupling by the Rhodopsin-Like Thyrotropin Receptor
%A Gunnar Kleinau
%A Holger Jaeschke
%A Catherine L. Worth
%A Sandra Mueller
%A Jorge Gonzalez
%A Ralf Paschke
%A Gerd Krause
%J PLOS ONE
%D 2012
%I Public Library of Science (PLoS)
%R 10.1371/journal.pone.0009745
%X In this study we wanted to gain insights into selectivity mechanisms between G-protein-coupled receptors (GPCR) and different subtypes of G-proteins. The thyrotropin receptor (TSHR) binds G-proteins promiscuously and activates both Gs (cAMP) and Gq (IP). Our goal was to dissect selectivity patterns for both pathways in the intracellular region of this receptor. We were particularly interested in the participation of poorly investigated receptor parts.
%U http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0009745