%0 Journal Article
%T Direct Reprogramming of Rat Neural Precursor Cells and Fibroblasts into Pluripotent Stem Cells
%A Mi-Yoon Chang
%A Dohoon Kim
%A Chun-Hyung Kim
%A Hoon-Chul Kang
%A Eungi Yang
%A Jung-Il Moon
%A Sanghyeok Ko
%A Junpil Park
%A Kyung-Soon Park
%A Kyung-Ah Lee
%A Dong-Youn Hwang
%A Young Chung
%A Robert Lanza
%A Kwang-Soo Kim
%J PLOS ONE
%D 2012
%I Public Library of Science (PLoS)
%R 10.1371/journal.pone.0009838
%X Given the usefulness of rats as an experimental system, an efficient method for generating rat induced pluripotent stem (iPS) cells would provide researchers with a powerful tool for studying human physiology and disease. Here, we report direct reprogramming of rat neural precursor (NP) cells and rat embryonic fibroblasts (REF) into iPS cells by retroviral transduction using either three (Oct3/4, Sox2, and Klf4), four (Oct3/4, Sox2, Klf4, and c-Myc), or five (Oct3/4, Sox2, Klf4, c-Myc, and Nanog) genes.
%U http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0009838