%0 Journal Article
%T Allele-Specific Regulation of Matrix Metalloproteinase-3 Gene by Transcription Factor NF¦ĘB
%A Veronika Souslova
%A Paul A. Townsend
%A Jelena Mann
%A Chris M. van der Loos
%A Anna Motterle
%A Fulvio D'Acquisto
%A Derek A. Mann
%A Shu Ye
%J PLOS ONE
%D 2012
%I Public Library of Science (PLoS)
%R 10.1371/journal.pone.0009902
%X Matrix metalloproteinase-3 (MMP3) is implicated in the pathogenesis and progression of atherosclerotic lesions. Previous studies suggested that MMP3 expression is influenced by a polymorphism (known as the 5A/6A polymorphism) in the promoter of the MMP3 gene and that this polymorphism is located within a cis-element that interacts with the transcription factor NF¦ĘB. In the present study, we sought to investigate whether MMP3 and NF¦ĘB were co-localized in atherosclerotic lesions and whether NF¦ĘB had differential effects on the two alleles of the MMP3 5A/6A polymorphism.
%U http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0009902