%0 Journal Article
%T Tumores oligodendrogliales: correlaci¨®n entre el genotipo tumoral e im¨¢genes de perfusi¨®n por RM
%A Meli
%A Francisco J.
%A Ingui
%A Jos¨¦
%A Badano
%A Federico
%A Martinetto
%A Horacio
%A Sevlever
%A Gustavo
%A Muggeri
%A Alejandro
%A Diez
%A Blanca
%J Revista argentina de radiolog£¿-a
%D 2011
%I Scientific Electronic Library Online
%X objective: to perform a retrospective assessment of the correlation between perfusion mr imaging, relative cerebral blood volume (rcbv) and genotype in patients with grade ii oligodendroglial neoplasms. materials and methods: eleven patients (7 men and 4 women), age range: 28-64 years, with grade ii oligodendroglial tumors (od) were studied using conventional mr and perfusion mr imaging (rcbv). genetic analysis was carried out in all patients to assess -1p/-19q genotype status. results: five patients with grade ii oligodendroglial tumors (45%) presented rcbv < 1.75 and intact 1p/19q. three patients had mixed gliomas, two of them had deletion in 1p/19q, and the other presented intact 1p/19 q. rcbv was > 1.75 in two patients and < 1.75 in the other patient. two patients with grade ii oligodendroglioma had an rcbv > 1.75, one with intact 1p/19q, and the other with deletion. the last patient presented a grade ii oligodendroglial tumor with rcbv < 1.75 and 1p/19q loss. conclusions: approximately 45% of patients with intact 1p/19q showed rcbv < 1.75, suggesting limited tumor neoangiogenesis. these findings could be important for the antiangiogenic therapy follow-up. studies in larger series could provide valuable information prior to surgery and contribute to a better management of these patients.
%K brain tumors
%K mri
%K pwi
%K tumoral genotype.
%U http://www.scielo.org.ar/scielo.php?script=sci_abstract&pid=S1852-99922011000100003&lng=en&nrm=iso&tlng=en