%0 Journal Article
%T Inhibition of mTOR by Rapamycin Abolishes Cognitive Deficits and Reduces Amyloid-¦Â Levels in a Mouse Model of Alzheimer's Disease
%A Patricia Spilman
%A Natalia Podlutskaya
%A Matthew J. Hart
%A Jayanta Debnath
%A Olivia Gorostiza
%A Dale Bredesen
%A Arlan Richardson
%A Randy Strong
%A Veronica Galvan
%J PLOS ONE
%D 2012
%I Public Library of Science (PLoS)
%R 10.1371/journal.pone.0009979
%X Reduced TOR signaling has been shown to significantly increase lifespan in a variety of organisms [1], [2], [3], [4]. It was recently demonstrated that long-term treatment with rapamycin, an inhibitor of the mTOR pathway[5], or ablation of the mTOR target p70S6K[6] extends lifespan in mice, possibly by delaying aging. Whether inhibition of the mTOR pathway would delay or prevent age-associated disease such as AD remained to be determined.
%U http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0009979