%0 Journal Article
%T Colesterol-IDL y par¨¢metros lip¨ªdicos en diab¨¦ticos tipo 2
%A Bonneau
%A G. A.
%A Castillo Rasc¨®n
%A M. S.
%A S¨¢nchez
%A R. A.
%A Pedrozo
%A W. R.
%A Castro Olivera
%A C.
%J Revista argentina de endocrinolog£¿-a y metabolismo
%D 2007
%I Scientific Electronic Library Online
%X diabetes mellitus is in the sixth death cause in the province of misiones. majority of patients die in relation with atherosclerosis, being dislipidemias one of the mechanism that explain this increased risk. we aimed to establish if there are significant differences for total cholesterol (tc), triglyceride (tg), hdl-cholesterol (hdlc), ldl-cholesterol (ldlc), idl-cholesterol (idlc), no-hdl cholesterol and the index tc/hdlc and tg/hdlc between diabetic patients type 2 and a control group, as well as comparing the idlc amount between both groups according to the dislipidemia phenotype. we studied 70 diabetic patients type 2 and 57 controls, with similar distribution in age, sex and body mass index. tc, tg, hdlc and ldlc were tested by enzymatic colorimetric methods with internal and external quality controls and the idlc by wikinski method. the results obtained in diabetic patients vs controls were (table n¡ã1): tc 214 ¡À49 vs 205¡À 34 mg/dl (p=0.488); tg 194¡À119 vs 128¡À65 mg/dl (p<0.001); hdlc 43¡À11 vs 50¡À13 mg/dl(p=0.001); ldlc 135¡À43 vs 132¡À 32 mg/dl (p=0.934); idlc 13.8¡À 8.7 vs 7.2¡À3.5 mg/dl (p<0.001) (figure n¡ã1); tc/hdlc 5.26 ¡À1.54 vs 4.40¡À 1.33 (p=0.001); tg/hdlc 5.01¡À3.95 vs 2.97¡À2.24 (p<0.001) y no-hdl cholesterol 172¡À48 vs 155¡À35 mg/dl (p=0.07); at a same electrophoretic pattern ( normolipemic (p=0.043), phenotype ii (p=0.006) or phenotype iv (p=0.001)),the idlc was higher in the first group (figure n¡ã2). the diabetic patients show a more atherogenic lipoprotein profile than the control group. the quantification of idlc improvement the assessment of atherogenic risk in type 2 diabetic patients, specially normolipemics.
%K diabetes type 2
%K lipoproteins
%K idl-cholesterol
%K atherogenic risk.
%U http://www.scielo.org.ar/scielo.php?script=sci_abstract&pid=S1851-30342007000400001&lng=en&nrm=iso&tlng=en