%0 Journal Article
%T Carcinoma de la mama triple negativo aspectos morfol¨®gicos y expresi¨®n de CK 5/6
%A Ram¨ªrez Casadiego
%A Ana Karina
%A Bianchi
%A Gino Italo
%J Revista Venezolana de Oncolog¨ªa
%D 2011
%I Scientific Electronic Library Online
%X breast cancer is heterogeneous disease classification parameters prognostic factors are not always predictors its clinical course. molecular genetics are categorizing in different ways, as the well-known morphologic classification. studies endorse specific group within this classifying system: basal-like carcinomas, has worst prognosis; tends to be triple-negative: er (-), rp (-), erb-b2(-); expresses basal cytokeratins, such as cytokeratin 5/6 (ck5/6). considered determining morphological aspects, frequency in which they express ck5/6 through immunohistochemistry, and contrasting them to existing clinical parameters. 91 carcinomas were selected between the years 2003 - 2008 and checked for ck5/6. or the aforementioned cases, 34 (37.4 %) resulted tn-ck5/6(+) and 57 (62.6 %) resulted tn-ck5/6(-). morphological aspects described for and carcinomas were observed in both groups, though they were more frequent in breast carcinomas tn-ck5/6(+). for this reason, detecting these tumors using immunohistochemistry is a practical, worthwhile, and convenient way to identify this group with the worst prognosis on our daily routines.
%K cancer
%K triple negative
%K basal
%K morphological
%K immunohistochemistry
%K ck5/6.
%U http://www.scielo.org.ve/scielo.php?script=sci_abstract&pid=S0798-05822011000100002&lng=en&nrm=iso&tlng=en