%0 Journal Article
%T Reac£¿£¿es adversas aos antibacilares em doentes internados: Gravidade e factores de risco
%A Vilari£¿a
%A Ana Sofia
%A Diogo
%A Nelson
%A Andr¨¦
%A Mota
%A Pina
%A Jaime
%J Revista Portuguesa de Pneumologia
%D 2010
%I Scientific Electronic Library Online
%X introduction: given mycobacterium tuberculosis£¿s characteristics, the treatment of tuberculosis (tb) infection is administered over a long period of time (for six months or more) with a combination of several drugs which could cause adverse reactions (ar). these can cause significant morbidity and compromise tuberculosis treatment regimens. aim: to determine the incidence and severity of and risk factors for major adverse reactions to antituberculosis drugs in in-hospital patients treated for active tuberculosis. methods: retrospective analysis of clinical records of patients admitted to pulido valente hospital (pulmonology unit iii) with active tb treated with anti-tuberculosis agents april 1999 to july 2007. adverse reactions resulting in modification or discontinuation of treatment or hospital admission were recorded. patients£¿ demographic characteristics and clinical data were used as independent variables. the relationship between independent variables and the frequency and severity of ar was studied using multivariate analysis using a logistic regression model. the data were analysed using the student t test, one-way anova and logistic regression. statistical analysis was performed using the spss (statistical package for the social sciences) version 15.0. results: we recorded 1400 in-hospital patients treated for active tb 1999 to 2007, of which 175 patients (12.5%), 118 male and 57 female, had at least one ar induced by antituberculosis agents, to a total of 192 events. hepatotoxicity was the most prevalent ar (83/47.4%), followed by skin reactions (55/31.4%) and gastrointestinal intolerance (24/13.7%). in 76 patients (43.4%) ar caused prolonged hospital stay. statistically significant differences (p<0.001) were observed in the average hospital stay (58.4 days for patients with ar and 26 days for patients without ar). isoniazid (62.2%) and rifampicin (51.9%) were the most frequently implicated drugs. it was possible to characterise the ar severity in 134 case
%K tuberculosis
%K adverse reaction (ar)
%K antituberculosis drug
%K hiv infection.
%U http://www.scielo.gpeari.mctes.pt/scielo.php?script=sci_abstract&pid=S0873-21592010000300006&lng=en&nrm=iso&tlng=en