%0 Journal Article
%T Role of CD14 in a Mouse Model of Acute Lung Inflammation Induced by Different Lipopolysaccharide Chemotypes
%A Adam A. Anas
%A Joppe W. R. Hovius
%A Cornelis van 't Veer
%A Tom van der Poll
%A Alex F. de Vos
%J PLOS ONE
%D 2012
%I Public Library of Science (PLoS)
%R 10.1371/journal.pone.0010183
%X Recognition of lipopolysaccharide (LPS) is required for effective defense against invading gram-negative bacteria. Recently, in vitro studies revealed that CD14 is required for activation of the myeloid differentiation factor (MyD)88-dependent Toll-like receptor (TLR)4 signaling pathway by smooth (S)-LPS, but not by rough (R)-LPS. The present study investigated the role of CD14 in induction of lung inflammation in mice by these different LPS chemotypes.
%U http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0010183