%0 Journal Article
%T Gcg-XTEN: An Improved Glucagon Capable of Preventing Hypoglycemia without Increasing Baseline Blood Glucose
%A Nathan C. Geething
%A Wayne To
%A Benjamin J. Spink
%A Michael D. Scholle
%A Chia-wei Wang
%A Yong Yin
%A Yi Yao
%A Volker Schellenberger
%A Jeffrey L. Cleland
%A Willem P. C. Stemmer
%A Joshua Silverman
%J PLOS ONE
%D 2012
%I Public Library of Science (PLoS)
%R 10.1371/journal.pone.0010175
%X While the majority of current diabetes treatments focus on reducing blood glucose levels, hypoglycemia represents a significant risk associated with insulin treatment. Glucagon plays a major regulatory role in controlling hypoglycemia in vivo, but its short half-life and hyperglycemic effects prevent its therapeutic use for non-acute applications. The goal of this study was to identify a modified form of glucagon suitable for prophylactic treatment of hypoglycemia without increasing baseline blood glucose levels.
%U http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0010175