%0 Journal Article
%T Dise£¿os de investigaci¨®n en epidemiolog¨ªa gen¨¦tica
%A Flores-Alfaro
%A Eugenia
%A Burguete-Garc¨ªa
%A Ana I.
%A Salazar-Mart¨ªnez
%A Eduardo
%J Revista Panamericana de Salud P¨²blica
%D 2012
%I Organizaci¨®n Panamericana de la Salud
%R 10.1590/S1020-49892012000100013
%X this article describes the features of the epidemiologic research designs most commonly used in genetic association studies. case-control studies are efficient in evaluating associations between candidate genes and disease. cohort studies, in contrast, yield a greater degree of causality but are not efficient for the initial exploration to identify gene-disease associations. cross-sectional studies are less expensive, require less time, and are useful for estimating the prevalence of diseases, risk factors, and genetic variants. family-based studies have been successful in finding alleles that confer greater risk for developing mendelian inheritance disorders.
%K genetic research
%K epidemiologic research design
%K genetic association studies
%K relative risk (public health).
%U http://www.scielosp.org/scielo.php?script=sci_abstract&pid=S1020-49892012000100013&lng=en&nrm=iso&tlng=en