%0 Journal Article
%T Toxicidad aguda y subaguda oral del extracto acuoso liofilizado de Rhizophora mangle L. en ratas
%A S¨˘nchez Perera
%A Luz Mar¨Şa
%A Fraga Ch¨˘vez
%A Ivis
%A Macebo Dorveny
%A Betty
%A Miranda
%A Rafael Lorenzo
%J Revista Cubana de Plantas Medicinales
%D 2008
%I ECIMED
%X rationale: rhizophora mangle l. is a highly distributed plant in cuba, whose effects on gastrointestinal ulcers by several mechanisms of action like cytoprotection, anti-secretion, prostaglandin pge2 depletion inhibition and wound healing have been scientifically proved. however, no toxicity studies have been so far conducted objectives: to determinate oral acute and sub-acute toxicity of dried aqueous extract from r. mangle bark. methods: the preclinical study of the dried aqueous extract from r. mangle was performed in acute models at a single dose (2000 mg/kg of body mass) and at daily repeated dose for 14 days at maximum therapeutic dose of 500 mg/kg of body mass. male and female sprague dawley rats divided into 5-rat groups of each sex per each experimental group. they were systematically observed until 14th day after the experiment when they were put away. results: their body weigh was the characteristic one corresponding to the species. there was no change in the organ weight and no anatomopathological signs with toxic effects were found. conclusions: toxic dose of the dried aqueous extract from r. mangle is over 2000 mg/kg according to a study on single dose. it is not toxic either at repeated doses of maximum therapeutic effect for 14 days; therefore, a wide range of safety is warranted.
%K rhizophora mangle
%K oral acute toxicity
%K oral subacute toxicity.
%U http://scielo.sld.cu/scielo.php?script=sci_abstract&pid=S1028-47962008000300008&lng=en&nrm=iso&tlng=en