%0 Journal Article
%T Actividad hepatoprotectora del extracto acuoso seco de Boerhavia erecta L. (tost¨®n) en ratas
%A Till¨¢n Cap¨®
%A Juana I.
%A Bueno Pav¨®n
%A Viviana
%A Carrillo Dom¨ªnguez
%A Carmen
%A Ag¨¹ero Fern¨¢ndez
%A Sara
%A Vald¨¦s Mart¨ªnez
%A Odalys
%J Revista Cubana de Plantas Medicinales
%D 2009
%I ECIMED
%X introduction: several in vitro studies of the aqueous extract from boerhavia erecta l. and the human hepatome cell line plc/prf/5 showed suppression in the formation of hepatitis b surface antigen (hbsag) and the inhibitory action of the antigen present in human serum contaminated with hepatitis b surface antigen. objectives: to determine the in vivo hepatoprotective effect of the aqueous extract from b. erecta. methods: male wistar rats were treated with 250 and 500mg of dry extract per kg intragastrically for 5 days, with induced hepatic damage on the last day, using 1 ml/kg of a 1:1 mixture of carbon tetrachloride and olive oil; after 24 hours, blood samples were taken to determine enzymatic activity of alanine-aminotransferase and for the euthanasia of the rats in order to perform the histological study of their livers. results: the extract caused significant reduction in the enzymatic activity of alanine-aminotransferase from treated rat sera and provided complete protection to the parenchyma of those animals which were administered 500 mg/kg dose. conclusions: the in vivo hepatoprotective effect of b. erecta aqueous extract was shown against carbon tetrachloride-induced damage.
%K rats
%K boerhavia erecta
%K hepatoprotective.
%U http://scielo.sld.cu/scielo.php?script=sci_abstract&pid=S1028-47962009000300005&lng=en&nrm=iso&tlng=en