%0 Journal Article
%T Interfer¨®n gamma recombinante como alternativa terap¨¦utica en ni£¿os con artritis idiop¨¢tica juvenil
%A Coto Hermosilla
%A Cecilia
%A Garc¨ªa Garc¨ªa
%A Idrian
%A D¨ªaz Rojo
%A Gisou
%A Bello Rivero
%A Iraldo
%A Bermudez Badell
%A Cimara
%A Valera Puente
%A Gloria
%A Cantero Oceguera
%A Dolores
%A Hern¨¢ndez Gonz¨¢lez
%A V¨ªctor
%A M¨¦ndez M¨¦ndez
%A Melba
%A G¨®mez Conde
%A Santa
%A Nodarse Cun¨ª
%A Hugo
%A L¨®pez Saura
%A Pedro
%J Revista Cubana de Pediatr£¿-a
%D 2010
%I Editorial Ciencias M¨¦dicas
%X introduction: the juvenile idiopathic arthritis (jia) is a collagen entity characterized by chronic synovitis and extra-articulation symptoms appearing before the 16 years old. gamma interferon (gamma-inf) showed its effectiveness in a prior trial with resistant and intolerant patients to other available gamma-inf therapies, thus authors assessed its effectiveness and safety as a modifier drug of the course of this entity. methods: an open clinical, no-controlled trial was carried out administering gammainf by intramuscular route in doses of 50 000 iu/kg (up to 1 x 106 iu) during two years. trial included 20 patients with jia: five had the pauciarticular type; nine had the polyarticular one and six had the systemic one. results: at treatment termination, 13 patients (65%) were assessed as respondents. figure of involved joints, the systemic symptoms and the erythrosedimentation values, and the quality questionnaire significantly decreased, as well as the figure of patients to continue consuming steroids and its dosage. treatment was well tolerated, except 2 patients. conclusions: gamma-inf decrease the expression of ccr-4 chemokine in children, but not in adults ones presenting this entity. we conclude that this cytokine may be an efficient therapeutical alternative in patients with jia; for its confirmation it is necessary more extent controlled studies.
%K recombinant gamma interferon
%K juvenile idiopathic arthritis
%K articular
%K systemic
%K chemokine.
%U http://scielo.sld.cu/scielo.php?script=sci_abstract&pid=S0034-75312010000100001&lng=en&nrm=iso&tlng=en