%0 Journal Article
%T Respuesta de anticuerpos IgG antileptospira en individuos inmunizados con vax-SPIRAL
%A Rodr¨ªguez
%A Islay
%A Mart¨ªnez
%A Raydel
%A Zamora
%A Yarelys
%A Rodr¨ªguez
%A Jos¨¦ Enrique
%A Fern¨¢ndez
%A Carmen
%A Obreg¨®n
%A Ana Margarita
%J Revista Cubana de Medicina Tropical
%D 2005
%I Centro Nacional de Informaci¨®n de Ciencias M¨¦dicas
%X a quantitative elisa for the detection of igg antibodies in response to the cuban vaccine against the human leptospirosis (vax-spiral) was applied to 930 volunteers' sera, 483 immunized with vax-spiral and 447 with a vaccine against hepatitis b. samples were taken before beginning the study, 21 days after the second dose and a year later. a high seroprevalence of antibodies to the vaccine serovars was observed before beginning the study. the initial value of the response doubled at 21 days of the second dose in 45 % of the individuals. there were markedly significant differences (p=0,000000) between both groups. a similar response to the three leptospiral serovars was found. after the year the levels of antibodies decreased; however, 23.1 % of the individuals were able to duplicate their level of antibodies regarding the initial moment, and the significant difference with the group that received the vaccine against hepatitis b still existed. the application of this cuban immunogen amomg the main risk groups was recommended.
%K leptospirosis
%K vax-spiral
%K igg antibodies
%K vaccine.
%U http://scielo.sld.cu/scielo.php?script=sci_abstract&pid=S0375-07602005000100006&lng=en&nrm=iso&tlng=en