%0 Journal Article
%T Susceptibilidad in vitro de aislamientos vaginales de Candida frente a clotrimazol y nistatina
%A Llovera Su¨˘rez
%A Vilma
%A Fern¨˘ndez Andreu
%A Carlos M.
%J Revista Cubana de Medicina Tropical
%D 2003
%I Centro Nacional de Informaci¨®n de Ciencias M¨¦dicas
%X the susceptibility in vitro of 123 isolates of candida against clotrimazole and nystatin was determined. the isolates were obtained by vaginal smears from 404 women that attended "ram¨®n gonzalez coro" gynecoobstetric hospital, in havana city according to the number of colonies obtained in the primary isolation, the strains were separated into 2 categories: colonization and infection. the inhibitory minimum concentration was determined for each antigunfal by a method of microdilution in casitone broth. the geometrical means of the imc values were higher against nystatin (1.08 mg/ml) than against clotrimazole (0.22 mg/ml), eventhough the features were similar ( ˇę 0.125 -16 mg/ml) for candida albicans, that was the most frequently isolated species (54.5 %), the geometrical means of the imc values were 0.17 and 0.16 mg/ml for clotrimazole and 0.71 and 0.92 for nystatin, in both categories. c. glabrata showed the highest imc values (16 mg/ml) against antifungals. only the isolates of c. lusitaniae showed a significant difference (p < 0.001) between the imc values of nystatin according to the number of colonies in the primary isolation. in isolates from women treated with clotrimazole and/or nystatin in previous episodes of candidiasis, there were observed more elevated values of the means of imc against nystatin than against clotrimazole, although this difference was not statistically remarkable.
%K microbial sensitivity tests [methods]
%K candida
%K clotrimazole
%K nystatin
%K in vitro.
%U http://scielo.sld.cu/scielo.php?script=sci_abstract&pid=S0375-07602003000300002&lng=en&nrm=iso&tlng=en