%0 Journal Article
%T Validaci¨®n de m¨¦todos anal¨ªticos de control de procesos de antitumorales inyectables
%A Garc¨ªa Pe£¿a
%A Caridad Margarita
%A Cunill Semanat
%A Edel
%A Cartaya Morales
%A Mayra
%A D¨ªaz de Arma
%A Anyisela
%A Curbelo Fonte
%A Yusleydis
%J Revista Cubana de Farmacia
%D 2010
%I ECIMED
%X alternative analytical methods were validated for the process control of 500 mg florouacil, 50 mg doxorrubicin and 50 mg methotrexate by spectrophotometry because of they are more simple and economic allowint to control the drugs quality in process anaslysis control. calibration curves of fluorouracil, doxorrubicin and methotrexate were plotted in interval from 60 to 140 %, where there were linear with correlation coeficients similar to 0.9998, 0.9999 and 0.9999, respectively; statistical text for intercept and slope were considered as non-significant. recoveries of 99.97, 99.98 and 99.35 % were achieved, respectively in study concentration interval and cochran and t-student tests were also non-significant. methods were specific, linear, precises and exacts in interval of study concentrations.
%K spectrophotometry
%K doxorrubicin
%K methotrexate
%K fluorouracil
%K injectable.
%U http://scielo.sld.cu/scielo.php?script=sci_abstract&pid=S0034-75152010000100003&lng=en&nrm=iso&tlng=en