%0 Journal Article
%T Expresi¨®n de las mol¨¦culas de adhesi¨®n en la anemia drepanoc¨ªtica
%A Mac¨ªas Abraham
%A Consuelo
%A del Valle P¨¦rez
%A L¨¢zaro O.
%A Socarr¨¢s Ferrer
%A Bertha B.
%A Bad¨ªa Mart¨ªnez
%A Teresita
%A Espinosa Mart¨ªnez
%A Edgardo
%A Svarch
%A Eva
%A Hern¨¢ndez Ram¨ªrez
%A Porfirio
%A Ballester Santovenia
%A Jos¨¦ M.
%J Revista Cubana de Hematolog£¿-a, Inmunolog£¿-a y Hemoterapia
%D 2009
%I Editorial Ciencias M¨¦dicas
%X in patients with drepanocytemia (dp) in basal state and with crises of painful vaso-occlusive (pvoc) authors studied the expression in mononuclear cells (mnc) and neutrophils, of lfa-1, vla-4, l-selectine and icam-1; in peripheral blood (pb), vcam-1 and cd34 molecules, and in red blood cells with different density, vla-4 and lutheran molecules, with specific monoclonal antibodies by indirect immunofluorescence by flux cytometry. in both groups there was a significant decrease in expression of lfa-1 and vla-4 molecules mnc and of lfa-1 in neutrophils of patients basal state; decrease in l-selectine molecule expression in mnc and in patients in basal state. increase of iacm-1 (cd54), cd34 and vcam-1 (cd106) in mnc and in peripheral blood of basal patients shows the presence of a permanent leukocyte activation state determined by the continuous subclinical inflammation. the significant increase of icam-1 in neutrophils and cd34 and vcam-1 in peripheral blood in both groups of patients with a higher increase of vcam-1 in patients in crises, shows the monocyte, lymphocyte , neutrophils, and of endothelial cells during the pvoc and the release of these latter to periphery. we note a higher expression of lfa-1, l-selectine and icam-1 molecules in neutrophils of patients with pvoc and a significant increase of cd18 molecule in mnc of patients with pvoc that may be explained by monocyte activation in vaso-occlusive phenomenon.
%K adhesion molecules
%K drepanocytemia
%K vascular endothelium
%K vaso-occlusion and inflammation.
%U http://scielo.sld.cu/scielo.php?script=sci_abstract&pid=S0864-02892009000200007&lng=en&nrm=iso&tlng=en