%0 Journal Article
%T Validaci¨®n del m¨¦todo anal¨ªtico para el control de la calidad y estudio de estabilidad de fenilefrina 10 % colirio
%A Monteagudo Licea
%A Raiza
%A Garc¨ªa Pe£¿a
%A Caridad Margarita
%A Botet Garc¨ªa
%A Martha
%A Troche Concepci¨®n
%A Yenilen
%A Montes de Oca Porto
%A Yanet
%J Revista Cubana de Farmacia
%D 2010
%I ECIMED
%X phenylephrine is used like mydiatric in eye examinations and other ophthalmic procedures. it is used as vasoconstrictor with local anesthetic agents. in present paper a high ressolution liquid chromatography analytical method was validated to quality control and stability studies of 10 % phenylephrine (eyedrops). mathod was based in separation of active principle through a lichrosorb ro-18 (5 ¦Ìm) (250 x 4 mm) chromatography column with uv detection at 280 nm using a mobile phase composed by a non-gasified mixture of methanol distilled water (1:1) with 1.1 g of 1-sodium octane-sulphonate by liter adjusted to ph 3,0 with phosphoric acid at a flow speed of 1.0 ml/min. analytical method was linear, accuracy, specific and exact in the interval of study concentrations.
%K hplc/method
%K phenylephrine
%K validation.
%U http://scielo.sld.cu/scielo.php?script=sci_abstract&pid=S0034-75152010000400008&lng=en&nrm=iso&tlng=en