%0 Journal Article
%T Microencapsulaci車n de tramadol en 芍cido polil芍ctico mediante secado por aspersi車n
%A L車pez Hern芍ndez
%A Orestes Dar赤o
%A G車mez Carril
%A Martha
%A Padr車n Yaquis
%A Alejandro Sa迆l
%A Toledo Rivero
%A Arturo
%A Toledo Sanchez
%A Carlos Alfredo
%A Reyes Sanchez
%A Enma
%A Reguera Ruiz
%A Edilso
%A Duque Rodr赤guez
%A Julio
%A L車pez Pelaez
%A Bertha
%J Revista Cubana de Farmacia
%D 2010
%I ECIMED
%X an interesting subject for pharmaceutical industry is the search of technologies to achieve pharmaceutical ways for administration and transportation of cytostatics, anti-inflammatories, peptides and hormones among other drugs implicating a reduction of its toxicity or a contolled releasing of active principle to increase its effectiveness. in present paper authors studied the influence of fluid flow in feeding, of atomization air and of driying; different physicochemical and morphological features (size, shape, porosity and distribution in the particles size, and the effectiveness of active principle encapsulation) of tramadol's microspheres. as result, it was possible to achieve microspheres of 18.93 ㊣ 2.31 米m with an spherical shape, a non-porous surface demostrating it by x-ray difractometry and tramadol encapsulation in the polymer.
%K tramadol
%K aspersion driying
%K microencapsulation.
%U http://scielo.sld.cu/scielo.php?script=sci_abstract&pid=S0034-75152010000400002&lng=en&nrm=iso&tlng=en