%0 Journal Article
%T Genetic Variants in REC8, RNF212, and PRDM9 Influence Male Recombination in Cattle
%A Cynthia Sandor equal contributor
%A Wanbo Li equal contributor
%A Wouter Coppieters
%A Tom Druet
%A Carole Charlier
%A Michel Georges
%J PLOS Genetics
%D 2012
%I Public Library of Science (PLoS)
%R 10.1371/journal.pgen.1002854
%X We use >250,000 cross-over events identified in >10,000 bovine sperm cells to perform an extensive characterization of meiotic recombination in male cattle. We map Quantitative Trait Loci (QTL) influencing genome-wide recombination rate, genome-wide hotspot usage, and locus-specific recombination rate. We fine-map three QTL and present strong evidence that genetic variants in REC8 and RNF212 influence genome-wide recombination rate, while genetic variants in PRDM9 influence genome-wide hotspot usage.
%U http://www.plosgenetics.org/article/info%3Adoi%2F10.1371%2Fjournal.pgen.1002854