%0 Journal Article
%T Exactitud del test ADN-HPV para la detecci¨®n de la enfermedad cervical de alto grado (NIC 2+) en mujeres con anormalidades citol¨®gicas (ASC-US y LSIL), afiliadas a la seguridad social en Bogot¨¢ (Colombia)
%A Isaza-Ruget
%A Mario Arturo
%A Perez
%A Gonzalo
%A Morales-Reyes
%A Olga Luc¨ªa
%A Deantonio-Su¨¢rez
%A Rodrigo
%A Alvarado-Heine
%A Catherine
%A Trujillo
%A Lina Mar¨ªa
%J Revista Colombiana de Obstetricia y Ginecolog¨ªa
%D 2009
%I Federaci¨®n Colombiana de Asociaciones de Obstetricia y Ginecolog¨ªa
%X objective: evaluating the accuracy of the hpv dna test as a complementary test for diagnosing highgrade cervical disease (high-grade squamous intra epithelia lesions-hsil) in women with minor cytological abnormalities (atypical squamous cells of undetermined significance asc-us) and low-grade squamous intraepithelial lesions (lsil). methodology: a diagnostic validity study based on a cross-sectional design was applied to 429 women who had had a cytological report of asc-us and/or lsil who were attending a health maintenance organisation¡¯s cervical cancer screening programme in bogot¨¢, colombia between january 2006 and october 2008. colposcopy reports and hpv-dna testresultswerecomparedwithpathologicalreports which were considered the gold standard. results: 344 (80.2%) of the 429 women had a cytological report of asc-us and 85 (19.8%) of them one for lsil. high-risk hpv infection prevalence was 52.9% and 75.7% in patients having an asc-us and lsil report, respectively. a biopsy specimen was obtained in 379 of the 429 participants and 24 high-grade cases (6.3%) were diagnosed. dna-hpv test sensitivity was 88% and specificity was 44% for detecting high-grade disease (cin 2+) in women having an asc-us and lsil cytology report . the presence of high-risk hpv virus was detected in 21 of the 24 hsil cases (87.5%). conclusion: the dna-hpv test¡¯s higher sensitivity compared to the pap smear (due to high npv) means that it could be considered a useful tool for stratifying risk and improving the diagnostic approach to premalignant lesions of the uterine cervix in patients having a cytological report of asc-us.
%K dna probe
%K hpv
%K papillomavirus infection
%K cervical intraepithelial neoplasia
%K cytology
%K colposcopy.
%U http://www.scielo.org.co/scielo.php?script=sci_abstract&pid=S0034-74342009000300002&lng=en&nrm=iso&tlng=en