%0 Journal Article
%T Evaluaci車n de la concentraci車n s谷rica de pepsin車geno como m谷todo de tamizaje para gastritis atr車fica y c芍ncer g芍strico
%A Oliveros
%A Ricardo
%A Albis
%A Rosario
%A Ceballos
%A Jorge
%A Ospina
%A Jorge
%A Villamizar
%A Jairo
%A Escobar
%A John
%A Rey
%A Mario
%A Muˋoz
%A Andr谷s
%A Arg邦ello
%A Pedro
%A Citelly
%A Diana
%A 
%J Revista Colombiana de Gastroenterologia
%D 2003
%I Asociaci車n Colombiana de Gastroenterolog赤a
%X gastric cancer has become a health problem in colombia, because of its very high incidence and late diagnosis. only 5% of all gastric cancers reported are diagnosed at an early stage. for these reasons a sensitive, adequated cost-effectiveness and with compliance screening program is required. in japan the i and ii pepsinogen tests have proved to be more effective than the fluoroscopic method for the detection of gastric cancer, the rate of detection being of 0.168% vs the 0.066% obtained fluoroscopically. based on this evidence, we decided to evaluate the use of the pepsinogen tests in two groups as follows: 66 gastric cancer patients and 110 members of the general population. from all of them we obtained blood samples for testing pep i and h. pylori antibodies, followed by endoscopy and biopsies. we defined the best cut-off point for pep i using a roc curve and found that < 150ng/ml was the best cut-off point with sensitivity of 84.3% and specificity of 71.3%. thus we concluded that pep i is a good method for detecting chronic atrophic gastritis and gastric cancer, but also due to the high h. pylori infection prevalence (97%) found the pep ii test must be performed in our population.
%K screening
%K pepsinogen
%K atrophic gastritis
%K gastric cancer.
%U http://www.scielo.org.co/scielo.php?script=sci_abstract&pid=S0120-99572003000200005&lng=en&nrm=iso&tlng=en