%0 Journal Article
%T Estandarizaci車n y validaci車n de una metodolog赤a anal赤tica para la determinaci車n de carbamazepina en plasma mediante extracci車n en fase s車lida y cromatograf赤a l赤quida de alta eficiencia
%A Rojas
%A Jaime H
%A Sierra
%A Noralba
%J Revista Colombiana de Ciencias Qu赤mico - Farmac谷uticas
%D 2007
%I Scientific Electronic Library Online
%X this paper describes the analytical results during validation of a reverse high performance liquid chromatography methodology for the assay of carbamazepine in human plasma, useful for their dosage in biodisponibility and bioequivalence studies. the stationary bounded phase used was octadecylsilane and the mobile phase was composed by a mixture of methanol-acetonitrile-water. the detection was performed by uv at 213 nm and lorazepam was utilized as internal standard. the method show linearity between 125 ng and 10 mcg/ml, amounts useful for the assay of carbamazepine in plasma.
%K carbamazepine (cbz)
%K lorazepam (lrz)
%K solid phase extraction
%K high performance liquid chromatography
%K octadecylsilane
%K uv detection
%K diode array detector
%K validation.
%U http://www.scielo.org.co/scielo.php?script=sci_abstract&pid=S0034-74182007000100005&lng=en&nrm=iso&tlng=en