%0 Journal Article
%T Os efeitos da ventila£¿£¿o mecanica no estresse oxidativo
%A Mazullo Filho
%A Jo£¿o Batista Raposo
%A Bona
%A Silvia
%A Rosa
%A Darlan Pase da
%A Silva
%A Fabiano Gomes da
%A Forgiarini Junior
%A Luiz Alberto
%A Dias
%A Alexandre Sim£¿es
%A Marroni
%A Norma Possa
%J Revista Brasileira de Terapia Intensiva
%D 2012
%I Associa??o de Medicina Intensiva Brasileira
%R 10.1590/S0103-507X2012000100004
%X objective: mechanical ventilation is a mainstay of therapy in intensive care units; however, its deleterious effects need to be assessed. therefore, we aimed to assess oxidative stress in patients admitted to an intensive care unit undergoing invasive mechanical ventilation. methods: this cross-sectional study included 12 invasive mechanical ventilation patients. blood samples (3 ml) were collected on the first and last days on invasive mechanical ventilation. thiobarbituric acid-reacting substances (tbars) were assessed in plasma, and superoxide dismutase (sod) and catalase (cat) were assessed in erythrocytes. results: the mean age was 64.8 ¡À 17.6 years, the tidal volume (vt) 382 ¡À 44.5 ml, and the apache ii score 15 ¡À 7. when initial and final tbars were compared, a significant difference was identified (3.54 ¡À 0.74 vs. 4.96 ¡À 1.47, p = 0.04). antioxidant enzymes showed no significant differences. correlations between pao2/fio2 and tbars (r = 0.4), sod and pao2/fio2 (r = 0.51) and apache ii and sod (r = 0.56) were identified. six patients died. conclusion: patients undergoing invasive mechanical ventilation can develop redox state changes, showing increased tbars and reduced antioxidant enzymes.
%K oxidative stress
%K intensive care units
%K respiration
%K artificial
%K thiobarbituric acid reactive substances.
%U http://www.scielo.br/scielo.php?script=sci_abstract&pid=S0103-507X2012000100004&lng=en&nrm=iso&tlng=en