%0 Journal Article
%T Influ¨ºncia da suplementa£¿£¿o aguda e cr£¿nica de creatina sobre marcadores enzim¨¢ticos de dano muscular de ratos sedent¨¢rios e exercitados com nata£¿£¿o
%A Souza
%A Renato Aparecido de
%A Miranda
%A Humberto
%A Xavier
%A Murilo
%A Salles
%A Belmiro Freitas de
%A Sim£¿o
%A Roberto
%A Os¨®rio
%A Rodrigo Al¨¦xis Lazo
%A Ribeiro
%A Wellington
%J Revista Brasileira de Educa£¿£¿o F¨ªsica e Esporte
%D 2010
%I Escola de Educa??o F¨ªsica e Esporte da Universidade de S?o Paulo (EEFEUSP)
%R 10.1590/S1807-55092010000300005
%X the aim of this study was to investigate the effects of the short-term (5 g.kg-1 to 1 week) and long-term (1 g.kg-1 to 4-8 weeks) creatine supplementation (cr) on the creatine kinase (ck), lactate dehydrogenaze (ldh) and aspartate aminotransferase (ast) plasmatic concentrations of sedentary and exercised (swimming to 80% of the tolerated maximum load) rats. seventy two wistar males rats (250 ¡À 10 g) were equally divided in four groups: sedentary rats without supplementation (con; n = 18); exercised rats without supplementation (nat; n = 18); sedentary rats with supplementation (cre; n = 18); exercised rats with supplementation (cre+nat; n = 18). at the end of the first, fourth and eighth weeks six animals of each group were sacrificed. the results demonstrated: 1) improvement of ck, ldh and ast in nat-1 and cre+nat-1 groups vs. con-1 and cre-1 groups after the first experimental week; 2) higher values of ck and ldh only nat-4 group after four experimental weeks; and 3) only ast from cre-8 group differed from other groups at the end of the eighth experimental week. these findings suggest that the cr supplementation: 1) does not affect the muscle damage on swimming exercised rats after one week of high intensity training; 2) could be able to reduce the muscle damage after 4 weeks of training; and 3) after eight weeks of cr supplementation, the muscle damage seems to be attenuated by the exercise, nullifying the effects of cr.
%K ergogenic resource
%K muscular damage
%K oxidative stress.
%U http://www.scielo.br/scielo.php?script=sci_abstract&pid=S1807-55092010000300005&lng=en&nrm=iso&tlng=en