%0 Journal Article
%T Development and in vitro evaluation of tablets based on the antichagasic benznidazole
%A Soares Sobrinho
%A Jos¨¦ Lamartine
%A Lima
%A Luciana Neiva Antunes
%A Perrelli
%A Diego Cavalcanti
%A Silva
%A Jeckson Luiz da
%A Medeiros
%A Fl¨¢via Patr¨ªcia Morais de
%A Soares
%A M£¿nica Felts de La Roca
%A Rolim Neto
%A Pedro Jos¨¦
%J Revista Brasileira de Ci¨ºncias Farmac¨ºuticas
%D 2008
%I Scientific Electronic Library Online
%R 10.1590/S1516-93322008000300007
%X this work aimed to verify the interferences caused by the use of excipients for immediate release tablets based on benznidazole obtained by direct compression and the accomplishment of a comparative study between the tablets developed and the reference medicine rochagantm, obtained by wet granulation. seven small-scale batches (ssb) were developed and aspects such as compressibility, powder flow, mean weight, friability, disintegration, hardness, assay, content uniformity, kinetic of release in vitro (dissolution) and drug/excipients physical-chemical compatibility were evaluated. based on the obtained results it can be verified that the analyzed powders presented adequated characteristics for the direct compression process, beyond the inexistent evidence of a physical-chemical interaction between the drug and the tested excipients. the tablets obtained from ssb i and iii were chosen for the comparative study with the reference medicine, demonstrating similarity with the statistically treated obtained results, becoming an alternative option of a medicine product for the treatment of chagas' disease with reduced cost and satisfactory quality.
%K benznidazole
%K excipients
%K direct compression
%K tablet
%K chagas' disease.
%U http://www.scielo.br/scielo.php?script=sci_abstract&pid=S1516-93322008000300007&lng=en&nrm=iso&tlng=en