%0 Journal Article
%T Avalia£¿£¿o da pectina fosfatada aplicada na forma£¿£¿o de filmes isolados: Material candidato a novos sistemas para libera£¿£¿o modificada de f¨¢rmacos
%A Souto-Maior
%A Jo£¿o Philype Andrade
%A Reis
%A Adriano Valim
%A Pedreiro
%A Liliane Neves
%A Cavalcanti
%A Osvaldo Albuquerque
%J Revista Brasileira de Ci¨ºncias Farmac¨ºuticas
%D 2008
%I Scientific Electronic Library Online
%R 10.1590/S1516-93322008000200006
%X phosphated pectin (pect-tmft) together with ¦Á-gluco-oligossacaride (bioecolians£¿) were incorporated into aqueous dispersion of polymethacrylate (eudragit£¿ rs 30 d) to obtain free films by the casting process (50oc) in teflon£¿ plate. pect-tmft and bioecolians£¿ were added into dispersions of eudragit £¿ rs 30 d at different rates: 90:05:05, 80:10:10 and 70:20:10 (4% p/v). triethyl citrate (tec) was used as plasticizer (20% of mass of the polymethacrylate). the proposed dispersions showed film formation ability. the free films were characterized by the determination of water vapour transmission (wvt), by the swelling index (ii%) in fluids of gastric simulation (fgs) and intestinal (fis) and by scanning electron microscopy (sem). the increase of modified polysaccharide and bioecolians£¿ in the films favored their permeability to the water vapour and their hydration degree when in fis (ph = 6.8). in that way, the obtained film in the concentration 70:20:10, can prevent the premature release of the drug in the up git when applied to develop oral solid systems coating. besides, the presence of pect-tmft and bioecolians£¿ can contribute to the specific membrane degradation by colonic microflora enzymes, making possible a modified release kinetics of drugs even with the existence of inter-individual variations of ph.
%K phosphated pectin
%K free films
%K ¦Á-gluco-olygosaccharides
%K eudragit£¿ rs 30 d
%K drugs [modified release].
%U http://www.scielo.br/scielo.php?script=sci_abstract&pid=S1516-93322008000200006&lng=en&nrm=iso&tlng=en