%0 Journal Article
%T Pr¨¦-condicionamento precoce da medula espinal isqu¨ºmica: pesquisa em coelhos
%A SADER
%A Albert Amin
%A CHIMELLI
%A Leila Maria Card£¿o
%A SADER
%A Soraya Lopes
%A BARBIERI NETO
%A Jos¨¦
%A COUTINHO NETO
%A Joaquim
%A ROSELINO
%A Jos¨¦ Eduardo de Salles
%A MAZZETTO
%A Sebasti£¿o Assis
%J Revista Brasileira de Cirurgia Cardiovascular
%D 1998
%I Sociedade Brasileira de Cirurgia Cardiovascular
%R 10.1590/S0102-76381998000200008
%X early preconditioning of the spinal cord was investigated in rabbits, as an eventual protection mechanism, immediately before a 30 min ischemic period. eight-seven new zealand rabbits divided into 6 groups were assigned to the study. ischemia of the spinal cord was induced by crossclamping (c) the abdominal aorta distal to the emergence of the left renal artery. preconditioning was stimulated by short and sometimes repetitive ischemic periods, underlined in the text, and followed by different periods of reperfusion. group i - control: in 20 animals the aorta was crossclamped for 30 min. in two of them (10%) motricity and sensitivity of the hind-legs and tail were entirely restored; the other 18(90%) became paraplegic. group ii - sham operation: 10 animals were operated as the ones in the previous group except for the fact that the aorta was not clamped. all of them (100%) had their sensitive and motor functions entirely restored. group iii - preconditioning: 10 animals - (c) 1 min £¿ 15 min£¿ (c) 30 min £¿ final reperfusion. all animals became paraplegic. group iv - preconditioning: 6 animals - (c) 1 min £¿ 5 min£¿ (c) 2 min £¿ 5 min £¿ (c) 2 min £¿ 5 min £¿ (c) 30 min final reperfusion. five rabgbits (83,33%) became paraplegic and 1 (16,66%) became monoplegic. group v - chlorpromazine: 20 animals were given chlorpromazine, intravenously, 2 mg/kg, 10 min before aortic crossclamping. eleven animals (55%) had their sensitive and motor functions reestablished and 9 (45%) became paraplegic. group vi - clorpromazine + preconditioning: 21 animals were given chlorpromazine as those of group v and were preconditioned as follows: (c) 1 min £¿ 5 min £¿ (c) 1 min £¿ 5 min £¿ (c) 30 min £¿ final reperfusion. nine animals (32.8%) recovered the sensitive and motor functions and 2(9.52%) experienced partial recovery. the remaining ones (47.68%) became paraplegic. statistical analysis of the results demonstrated that: 1) there was no significant difference between groups iii and iv, and when bot
%K isquemic preconditioning
%K spinal chord
%K spinal chord protection [methods].
%U http://www.scielo.br/scielo.php?script=sci_abstract&pid=S0102-76381998000200008&lng=en&nrm=iso&tlng=en