Mucinous breast carcinoma is a rare malignant tumor (1% - 4% of breast cancers), generally associated with a favorable prognosis. Its management is multidisciplinary; adjuvant radiation therapy aims to reduce the risk of locoregional recurrence. Short hypofractionated regimens, including the FAST-Forward protocol, are increasingly used in older patients due to their convenience and demonstrated efficacy in standard series of ductal carcinoma. We report the case of an 86-year-old female patient with mucinous carcinoma of the left breast classified as cT3N0M0; treated with surgery, hormone therapy, and adjuvant radiotherapy according to the FAST-Forward regimen (26 Gy in 5 fractions over one week), using a three-dimensional technique that allows for optimal coverage without exceeding the dose limits for at-risk organs. The treatment was well tolerated, and the patient did not experience any acute or late radiation-induced toxicity. After 15 months of follow-up, no locoregional recurrence was observed, and functional quality of life was preserved. This case demonstrates that the hypofractionated FAST-Forward regimen may be a safe and practical option for the adjuvant management of mucinous breast carcinoma in elderly patients. Larger series and long-term follow-up are needed to confirm the safety and efficacy specific to this histological subtype.
Cite this paper
Ziani, K. , Morchid, S. , Aarim, I. E. K. , Chaib, S. , Kharmoum, J. , Chraibi, M. , Merssetti, W. and Sellal, N. (2026). FAST-Forward Hypofractionated Radiotherapy in Mucinous Breast Carcinoma: A Case Report. Open Access Library Journal, 13, e15499. doi: http://dx.doi.org/10.4236/oalib.1115499.
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