Asthma is a chronic inflammatory disease of the airways manifested by
reversible airflow obstruction and airway hyperresponsiveness. While recent
research has mapped several genes as possible factors predisposing to asthma,
interleukin-13 remains one of the most commonly found genes in various
populations. IL-13 is a pleiotropic TH2 cytokine which has been linked to cause
an increase in goblet cell differentiation, activation of fibroblasts,
elevation of bronchial hyperresponsiveness and switching of B cell antibody
from IgM to IgE. The aim of this review is to study and identify the three main
single-nucleotide polymorphisms of IL-13 (IL13 R130Q, IL-13Rα1 and IL-13 A2044G) that have been
linked to asthma in children, and to understand their respective roles in the
pathogenesis of this disease.
Cite this paper
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