%0 Journal Article
%T Estrat¨¦gia de simplifica£¿£¿o molecular no planejamento racional de f¨¢rmacos: a descoberta de novo agente cardioativo
%A Barreiro
%A Eliezer J.
%J Qu¨ªmica Nova
%D 2002
%I Sociedade Brasileira de Qu¨ªmica
%R 10.1590/S0100-40422002000700018
%X in this article are described examples of the successful use of molecular simplification strategy in the discovery of new drugs from bioactive natural products and synthetic compounds. the discovery of a new cardiotonic derivative (37, 2-thienylidene-3,4-methylenedioxybenzoylhydrazine; lassbio-294), efficiently synthesized from brazilian natural product and structurally designed by molecular simplification of active pyridazinone compounds reported in the literature, is described. a brief description of the pharmacological profile of this new cardiotonic lead-compound, belonging to the n-acylhydrazone (nah) class, is also reported herein.
%K new cardiotonic derivative
%K bioactive n-acylhydrazone compound
%K lassbio-294.
%U http://www.scielo.br/scielo.php?script=sci_abstract&pid=S0100-40422002000700018&lng=en&nrm=iso&tlng=en