%0 Journal Article
%T Anest¨¦sicos locais: intera£¿£¿o com membranas biol¨®gicas e com o canal de s¨®dio voltagem-dependente
%A Araujo
%A Daniele Ribeiro de
%A Paula
%A Eneida de
%A Fraceto
%A Leonardo Fernandes
%J Qu¨ªmica Nova
%D 2008
%I Sociedade Brasileira de Qu¨ªmica
%R 10.1590/S0100-40422008000700032
%X many theories about the mechanism of action of local anesthetics (la) are described in the literature. two types of theories can be distinguished: those that focus on the direct effects of la on their target protein in the axon membranes, i.e. the voltage-gated sodium channel and the ones that take into account the interaction of anesthetic molecules with the lipid membrane phase for the reversible nerve blockage. since there is a direct correlation between la hydrophobicity and potency, it is crucial to take this physico-chemical property into account to understand the mechanism of action of la, be it on the sodium channel protein, lipid(s), or on the whole membrane phase.
%K local anesthetic
%K membrane
%K voltage-gated sodium channel.
%U http://www.scielo.br/scielo.php?script=sci_abstract&pid=S0100-40422008000700032&lng=en&nrm=iso&tlng=en