%0 Journal Article
%T In vitro trypanocidal evaluation of pinane derivatives from essential oils of ripe fruits from Schinus terebinthifolius Raddi (Anacardiaceae)
%A Sartorelli
%A Patricia
%A Santana
%A Jefferson S.
%A Guadagnin
%A Rafael C.
%A Lago
%A Jo£¿o Henrique G.
%A Pinto
%A ¨¦rika G.
%A Tempone
%A Andr¨¦ G.
%A Stefani
%A H¨¦lio A.
%A Soares
%A Marisi G.
%A Silva
%A Adalberto M. da
%J Qu¨ªmica Nova
%D 2012
%I Sociedade Brasileira de Qu¨ªmica
%R 10.1590/S0100-40422012000400017
%X essential oils of ripe fruits from schinus terebinthifolius (anacardiaceae), obtained using a pilot extractor and a clevenger apparatus were chemically characterized. due the high amount of (-)- ¦Á-pinene in both oils, this monoterpene was tested against the protozoan parasite trypanosoma cruzi, showing a moderate potential (ic50 63.56 ¦Ìg/ml) when compared to benznidazole (ic50 43.14 ¦Ìg/ml). otherwise, (-)- ¦Á-pinene oxide did not showed anti-trypanosomal activity (ic50 > 400 ¦Ìg/ml) while (-)-pinane showed an ic50 of 56.50 ¦Ìg/ml. the obtained results indicated that the epoxydation of ¦Á-pinene results to the loss of the anti-parasitic activity while its hydrogenation product, contributed slightly to the increased activity.
%K schinus terebinthifolius raddi
%K anacardiaceae
%K trypanocidal activity.
%U http://www.scielo.br/scielo.php?script=sci_abstract&pid=S0100-40422012000400017&lng=en&nrm=iso&tlng=en