%0 Journal Article
%T Mismatch and G-Stack Modulated Probe Signals on SNP Microarrays
%A Hans Binder
%A Mario Fasold
%A Torsten Glomb
%J PLOS ONE
%D 2012
%I Public Library of Science (PLoS)
%R 10.1371/journal.pone.0007862
%X Single nucleotide polymorphism (SNP) arrays are important tools widely used for genotyping and copy number estimation. This technology utilizes the specific affinity of fragmented DNA for binding to surface-attached oligonucleotide DNA probes. We analyze the variability of the probe signals of Affymetrix GeneChip SNP arrays as a function of the probe sequence to identify relevant sequence motifs which potentially cause systematic biases of genotyping and copy number estimates.
%U http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0007862