%0 Journal Article %T The Catalytic Subunit of Protein Phosphatase 1 Gamma Regulates Thrombin-Induced Murine Platelet ¦ÁIIb¦Â3 Function %A Francisca C. Gushiken %A Han Hyojeong %A Subhashree Pradhan %A Kimberly W. Langlois %A Nawaf Alrehani %A Miguel A. Cruz %A Rolando E. Rumbaut %A K. Vinod Vijayan %J PLOS ONE %D 2012 %I Public Library of Science (PLoS) %R 10.1371/journal.pone.0008304 %X Hemostasis and thrombosis are regulated by agonist-induced activation of platelet integrin ¦ÁIIb¦Â3. Integrin activation, in turn is mediated by cellular signaling via protein kinases and protein phosphatases. Although the catalytic subunit of protein phosphatase 1 (PP1c) interacts with ¦ÁIIb¦Â3, the role of PP1c in platelet reactivity is unclear. %U http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0008304