%0 Journal Article
%T Antibacterial activity of orsellinates
%A Gomes
%A Alcir Teixeira
%A Smania J¨˛nior
%A Artur
%A Seidel
%A Cintia
%A Smania
%A Elza de F¨˘tima Albino
%A Honda
%A Neli Kika
%A Roese
%A Fernanda Mesquita
%A Muzzi
%A Rozanna Marques
%J Brazilian Journal of Microbiology
%D 2003
%I Sociedade Brasileira de Microbiologia
%R 10.1590/S1517-83822003000300002
%X in order to obtain new compounds with antibacterial activity, the derivatives 2,4-dihydroxy-6-methylbenzoic acid (orsellinic acid) and 2,4-dihydroxy-6-methylbenzoates (orsellinates) were obtained through alcoholyses of lecanoric acid. all these substances were tested against gram-positive and gram-negative bacteria by a microdilution method. staphylococcus aureus, xanthomonas campestris var. vesicatoria and ralstonia solanacearum were most sensitive to n-propyl 2,4-dihydroxy-6-methylbenzoate, n-pentyl 2,4-dihydroxy-6-methylbenzoate and n-hexyl 2,4-dihydroxy-6-methylbenzoate with mic (minimal inhibitory concentration) values ranging from 62.5 to 7.8 ¦ĚgˇÁml1. these results showed that homologation in carbon chain may lead to compounds with more pronunced activities.
%K orsellinates
%K lecanoric acid
%K orsellinic acid
%K antibacterial activity.
%U http://www.scielo.br/scielo.php?script=sci_abstract&pid=S1517-83822003000300002&lng=en&nrm=iso&tlng=en