%0 Journal Article
%T Cytokines in innate and acquired immunity to Trypanosoma cruzi infection
%A Abrahamsohn
%A I.A.
%J Brazilian Journal of Medical and Biological Research
%D 1998
%I Associa??o Brasileira de Divulga??o Cient¨ªfica
%R 10.1590/S0100-879X1998000100015
%X resistance to trypanosoma cruzi infections is critically dependent on cytokine-mediated activation of cell-mediated immune effector mechanisms. this review focuses on the role of il-10, tnf-a, ifn-g and il-12 in controlling t. cruzi replication by the innate and specific immune systems of the vertebrate host. a study performed on mice with disrupted recombinase-activating genes (rag/ko), which lack t and b lymphocytes, revealed the importance of il-12, ifn-g and tnf-a in the resistance against t. cruzi mediated by the innate immune system. in addition, data from experiments using il-10 ko, rag/ko and double rag/il-10 ko mice indicating an in vivo regulatory role of il-10 in innate and t. cruzi-specific immunity are discussed
%K trypanosoma cruzi
%K interferon-gamma
%K interleukin-12
%K tnf-alpha
%K interleukin-10
%K innate immunity
%K knock-out mice.
%U http://www.scielo.br/scielo.php?script=sci_abstract&pid=S0100-879X1998000100015&lng=en&nrm=iso&tlng=en