%0 Journal Article
%T Statistical voxel-wise analysis of ictal SPECT reveals pattern of abnormal perfusion in patients with temporal lobe epilepsy
%A Amorim
%A B¨˘rbara Juarez
%A Etchebehere
%A Elba Cristina S¨˘ de Camargo
%A Camargo
%A Edwaldo Eduardo
%A Rio
%A Pablo Augusto
%A Bonilha
%A Leonardo
%A Rorden
%A Chris
%A Li
%A Li Min
%A Cendes
%A Fernando
%J Arquivos de Neuro-Psiquiatria
%D 2005
%I Academia Brasileira de Neurologia - ABNEURO
%R 10.1590/S0004-282X2005000600014
%X objective: to investigate the pattern of perfusion abnormalities in ictal and interictal brain perfusion spect images (bsi) from patients with temporal lobe epilepsy (tle). method: it was acquired interictal and ictal bsi from 24 patients with refractory tle. bsis were analyzed by visual inspection and statistical parametric mapping (spm2). statistical analysis compared the patients group to a control group of 50 volunteers. the images from patients with left-tle were left-right flipped. results: it was not observed significant perfusional differences in interictal scans with spm. ictal bsi in spm analysis revealed hyperperfusion within ipsilateral temporal lobe (epileptogenic focus) and also contralateral parieto-occipital region, ipsilateral posterior cingulate gyrus, occipital lobes and ipsilateral basal ganglia. ictal bsi also showed areas of hypoperfusion. conclusion: in a group analysis of ictal bsi of patients with tle, voxel-wise analysis detects a network of distant regions of perfusional alteration which may play active role in seizure genesis and propagation.
%K brain perfusion
%K spect
%K spm
%K seizures
%K epilepsy.
%U http://www.scielo.br/scielo.php?script=sci_abstract&pid=S0004-282X2005000600014&lng=en&nrm=iso&tlng=en