%0 Journal Article
%T Expression of p53, Ki-67 and c-erb B2 in growth hormone-and/or prolactin-secreting pituitary adenomas
%A Botelho
%A Carlos Henrique A.
%A Magalh£żes
%A Albino Ver£żosa de
%A Mello
%A Paulo Andrade de
%A Schmitt
%A Fernando C.
%A Casulari
%A Luiz Augusto
%J Arquivos de Neuro-Psiquiatria
%D 2006
%I Academia Brasileira de Neurologia - ABNEURO
%R 10.1590/S0004-282X2006000100013
%X the subcellular events implicated on the formation and behavior of pituitary adenomas are not fully understood. in this study we investigated the presence of p53, ki-67 and c-erb b2 in 38 pituitary adenomas with immunohistochemical positivity for gh and prolactin (n=26; 68.4%), for prolactin (n=9; 23.7%) and for gh (n=3. 7.8%). the analyses revealed the following results: 24 (63.2%) tumors expressed variable positivity for c-erb b2, 11 (28.9%) expressed p53 positivity and 11 (28.9%) tumors were variably positive for ki-67. our results demonstrated a high percentage of gh/prolactin-, prolactin- and gh-secreting tumors with immunohistochemical positivity for c-erb b2. once this membrane receptor is related to growth factors egf and tgfa and both have a definite effect on tumor growth, our data suggest a possible role for c-erb b2 on the evolution of these tumors.
%K pituitary adenomas
%K growth hormone
%K prolactin
%K p53
%K ki-67
%K c-erb b2
%K immunohistochemistry.
%U http://www.scielo.br/scielo.php?script=sci_abstract&pid=S0004-282X2006000100013&lng=en&nrm=iso&tlng=en