%0 Journal Article
%T Role of IL-4 in an experimental model of encephalitis induced by intracranial inoculation of herpes simplex virus-1 (HSV-1)
%A Vilela
%A M¨˘rcia Carvalho
%A Campos
%A Roberta Dayrell de Lima
%A Mansur
%A Daniel Santos
%A Rodrigues
%A David Henrique
%A Queiroz
%A Norinne Lacerda
%A Lima
%A Graciela Kunrath
%A Rachid
%A Milene Alvarenga
%A Kroon
%A Erna Geessien
%A Campos
%A Marco AntŁżnio
%A Teixeira
%A AntŁżnio L¨˛cio
%J Arquivos de Neuro-Psiquiatria
%D 2011
%I Academia Brasileira de Neurologia - ABNEURO
%R 10.1590/S0004-282X2011000200019
%X herpes simplex virus-1 (hsv-1) is a pathogen that may cause severe encephalitis in humans. in this study, we aimed to investigate the role of interleukin-4 (il-4) in a model of hsv-1 brain infection. il-4 knockout (il-4-/-) and wild type (wt) c57bl/6 mice were inoculated with 104 plaque-forming units of hsv-1 by the intracranial route. histopathologic analysis revealed a distinct profile of infiltrating cells at 3 days post-infection (dpi). infected wt mice presented mononuclear inflammatory cells while il-4-/- mice developed meningoencephalitis with predominance of neutrophils. il-4-/- mice had diminished leukocyte adhesion at 3 dpi when compared to infected wt animals in intravital microscopy study. conversely no differences were found in cerebral levels of cxcl1, cxcl9, ccl3, ccl5 and tnf-¦Á between wt and il-4-/- infected mice. il-4 may play a role in the recruitment of cells into central nervous system in this acute model of severe encephalitis caused by hsv-1.
%K herpes simplex virus type 1
%K il-4
%K neuroinflammation.
%U http://www.scielo.br/scielo.php?script=sci_abstract&pid=S0004-282X2011000200019&lng=en&nrm=iso&tlng=en