%0 Journal Article %T Analysis of the immunohistochemical expressions of p53, bcl-2 and Ki-67 in colorectal adenocarcinoma and their correlations with the prognostic factors %A Menezes %A Hunaldo Lima de %A Juc¨¢ %A M¨¢rio Jorge %A Gomes %A Edmundo Guilherme de A. %A Nunes %A Ben¨ªcio L. Bulh£¿es B. P. %A Costa %A Henrique Oliveira %A Matos %A Delcio %J Arquivos de Gastroenterologia %D 2010 %I Instituto Brasileiro de Estudos e Pesquisas de Gastroenterologia - IBEPEGE %R 10.1590/S0004-28032010000200005 %X context: search of tumors markers that allow treatment with higher survival rates, and indicate the response to treatment and recurrence of cancer objective: to analyze the immunoexpression of the proteins p53, bcl-2 and ki-67 in colorectal adenocarcinoma and correlate them with the clinical-pathological prognostic factors. method: tissue microarray paraffin blocks were made from colorectal adenocarcinoma tissue resected from 82 patients who had undergone surgery but not chemotherapy or radiotherapy, at "hospital s£¿o paulo", s£¿o paulo, sp, brazil, between 2002 and 2005. thin sections (4 ¦Ìm) were subjected to immunohistochemical reactions, and immunoexpression staining scores were obtained. the scores were correlated with the degree of cell differentiation, staging, disease-free interval, recurrence, survival and specific mortality. the study variables were analyzed using the chi-square and kaplan-meier tests to investigate associations with the markers. the significance of the differences between the curves of the disease-free interval and survival was analyzed using the logrank and wilcoxon tests. results: the immunohistochemical expression of p53 was positive in 70 tumors (85.4%) and negative in 12 (14.6%). the expression of bcl-2 was positive in 26 (31.7%) and negative in 56 (68.3%). the expression of ki-67 was positive in 62 (75.6%) and negative in 20 (24.4%). there was no statistically significant correlation between the expressions of these markers separately or in conjunction, in relation to the degree of cell differentiation, staging, disease-free interval, survival and specific mortality. in relation to recurrence, there was a statistically significant correlation with positive expression of ki-67 (p = 0.035). conclusion: the immunohistochemical expression of ki-67 in colorectal cancer is associated with recurrence of this disease. %K colorectal neoplasms %K adenocarcinoma %K immunohistochemistry %K tumor suppressor protein p53 %K proto-oncogene proteins c-bcl-2 %K bcl-2 homologous antagonist-killer protein. %U http://www.scielo.br/scielo.php?script=sci_abstract&pid=S0004-28032010000200005&lng=en&nrm=iso&tlng=en