%0 Journal Article %T HLA class I haplotypes and progression of primary open-angle glaucoma %A Zenha %A F¨˘bio %A Castadelli %A Rosistele Maria Oliveira Bezerra %A Deghaide %A Neifi Hassam Saloum %A Donadi %A Eduardo Antonio %A Rodrigues %A Maria de Lourdes Veronese %J Arquivos Brasileiros de Oftalmologia %D 2011 %I Conselho Brasileiro de Oftalmologia %R 10.1590/S0004-27492011000200003 %X purpose: to verify if patients with primary open-angle glaucoma with hla class i haplotypes (a9-b12, a2-b40, a1-b8) associated with this disease may have a greater rate of progression than patients who do not present these haplotypes. methods: anatomical and functional glaucoma evaluation (cup-to-disc ratio and visual field) of 25 patients (six of them with one of the haplotypes associated with glaucoma) followed at the glaucoma outpatient clinic of the university hospital, ribeir£żo preto school of medicine, s£żo paulo university (hcfmrp-usp) for ten years after typing of their hla antigens in order to compare with their previous condition. results: a greater increase of the cup-to-disc ratio was observed in patients with hla haplotypes associated with primary open-angle glaucoma predisposition. however, no significant differences in functional damage progression or in retinal nerve fibers loss were detected between them and other patients with glaucoma. conclusion: the present results indicate an association of class i hla haplotypes with progression of anatomic alterations of the optic nerve head in glaucomatous patients. %K glaucoma %K open-angle %K hla antigens %K visual fields %K haplotypes. %U http://www.scielo.br/scielo.php?script=sci_abstract&pid=S0004-27492011000200003&lng=en&nrm=iso&tlng=en