%0 Journal Article
%T Influ¨ºncia do hipotireoidismo induzido por propiltiouracil na mucosa gengival do rato
%A Douglas
%A Nicol¨¢s
%A Olmedo
%A Pedro
%A Douglas
%A Carlos Roberto
%A Monte
%A Osmar
%J Arquivos Brasileiros de Endocrinologia & Metabologia
%D 2006
%I Sociedade Brasileira de Endocrinologia e Metabologia
%R 10.1590/S0004-27302006000500015
%X this work aimed at verifying the influence of propilthiouracil (ptu)-induced thyroid hormone deficiency on gingival mucosa of young male rats, measuring total protein concentration, collagen content and dna concentration as indices of cellular population. fifty sprague-dawley rats were used. the animals were grouped in: ptu-treated (i.p. 10 mg/d) and control rats (c). the experience was maintained for a period of 10 weeks. total protein content of gingival mucosa tissue was determined by the lowry method; hydroxyprolin rate, as prototype aminoacid of collagen, was determined using the newman method, and dna concentration was measured by burton's methodology. the results showed decreased amounts of ptu-treated rats gingival total protein content (ptu= 41.23 ¡À 24.05 vs. c= 63.36 ¡À 18.05); no alterations were seen in hydroxyprolin concentration neither in dna content of ptu treated rats, respectively (ptu= 2.18 ¡À 1.48 vs. c= 2.29 ¡À 1.51) and (ptu= 0.33 ¡À 0.19 vs. c= 0.46 ¡À 0.41). thus, ptu treatment promotes a decrease in total protein content of rat gingival mucosa that may be interpreted as a decrease in protein synthesis induced by the hypothyroid condition, but with no alteration either in collagen or nucleic acid rates.
%K hypothyroidism
%K propilthiouracil
%K gingiva
%K proteins
%K collagen
%K dna.
%U http://www.scielo.br/scielo.php?script=sci_abstract&pid=S0004-27302006000500015&lng=en&nrm=iso&tlng=en