%0 Journal Article
%T A Defici¨ºncia de vitamina d est¨¢ associada com n¨ªveis aumentados de il-17 e tnf¦Á em pacientes com insufici¨ºncia card¨ªaca cr£¿nica
%A Milovanovic
%A Milena
%A Pesic
%A Gordana
%A Nikolic
%A Valentina
%A Jevtovic-Stoimenov
%A Tatjana
%A Vasic
%A Karin
%A Jovic
%A Zorica
%A Deljanin-Ilic
%A Marina
%A Pesic
%A Srdjan
%J Arquivos Brasileiros de Cardiologia
%D 2012
%I Sociedade Brasileira de Cardiologia - SBC
%R 10.1590/S0066-782X2012005000019
%X background: recent studies revealed a strong association between vitamin d (vd) status and chronic heart failure (chf). it is now commonly considered that proinflammatory immune response underlies chf development. objective: since vd expresses anti-inflammatory properties, we investigated its impact on cytokines implicated in chf, such as tnf¦Á and il-17, in patients suffering from chf. methods: blood was obtained from forty patients with chf secondary to hypertension and/or coronary heart disease. vd status, il-17 and tnf¦Álevels were assessed using 25-hydroxy vd3 eia and cytokine elisas. clinical assessment and echocardiography was also performed. results: elderly patients with chf in nis (southeast europe, latitude 43on) exhibited 25-hydroxy vd3 levels below normal. our data identified that patients with chf secondary to hypertension have significantly lower 25-hydroxy vd3, increased tnf¦Á and il-17a levels in comparison to donors with chf secondary to coronary disease. conclusion: this study reveals that even in regions with a lot of sunny days vd deficiency represents a concerning issue. data suggest that impaired vd status contributes to high il-17 and tnf¦Á levels and thereby may support chf development.
%K vitamin d deficiency
%K heart failure
%K interleukin-17
%K hypertension.
%U http://www.scielo.br/scielo.php?script=sci_abstract&pid=S0066-782X2012000300009&lng=en&nrm=iso&tlng=en