%0 Journal Article
%T HLA-A24: factor de riesgo en retinopat¨ªa diab¨¦tica proliferante
%A Asensio-S¨¢nchez
%A V.M.
%A Rodr¨ªguez-Delgado
%A B.
%A Garc¨ªa-Herrero
%A E.
%A Cabo-Vaquera
%A V.
%A Garc¨ªa-Loygorri
%A C.
%J Archivos de la Sociedad Espa£¿ola de Oftalmolog¨ªa
%D 2007
%I Scientific Electronic Library Online
%R 10.4321/S0365-66912007001200007
%X objective: proliferative diabetic retinopathy (pdr) is characterized by a progressive visual impairment in young people. human leucocyte antigen (hla)-a24 is a well-established factor associated with the pancreatic islets of langerhans lost in this process. our aim was to study further the relationship of the hla-a24 associated with pdr. materials and methods: we evaluated a group of patients with pdr (n=95) and a healthy control group (n= 60). hla-a24 for each participant in the study was determined by molecular hybridization techniques. results: the control group showed a lower frequency of hla-a24 compared with the pdr group (p = 0.043). hla-a24 was associated with pdr (or = 5.4; 95% ci= 3.2-7.6; p< 0.001). conclusions: hla-a24 is not a protective factor for pdr, but is a risk factor of its development.
%K insulin-dependent diabetes
%K proliferative diabetic retinopathy
%K hla
%K hla-a24
%K risk factor.
%U http://scielo.isciii.es/scielo.php?script=sci_abstract&pid=S0365-66912007001200007&lng=en&nrm=iso&tlng=en