%0 Journal Article
%T Efectos de la administraci¨®n cr¨®nica de alcohol sobre la conducta motora y su relaci¨®n con el sistema colin¨¦rgico muscarinico en ratas Sprague Dawley bajo estr¨¦s discontinuos
%A Chac¨®n Lozs¨¢n
%A Francisco J
%A Bonfante-Cabarcas
%A Rafael Armando
%A Daza
%A Damelis
%A Garcia
%A Douglas
%J Archivos Venezolanos de Farmacolog¨ªa y Terap¨¦utica
%D 2009
%I Scientific Electronic Library Online
%X alcohol consumption and stress are health problems, which affects the cholinergic muscarinic receptor (cmr) system. here we studied the effect of both phenomena on cmr functionality and densities. methods: 43 sprague dawley rats were divided in 4 groups: control (n=11), stress (n=10), alcohol (n=10) and alcohol-stress (n=9). alcohol groups received 10% ethanol ad libitum in substitution of water every day, stress groups were submitted 3 days at week to 5 min force swimming at 5¡ãc. results: rats that had alcohol displayed addiction and hypermotility, the effect was higher at alcohol-stress group. scopolamine significantly increased motility in all groups. no differences were observed at rotarod performance. cmr density was decreased in hippocampus of rats belonging to alcohol group. conclusion: alcohol induces motor disturbances related to cmr system.
%K alcohol
%K stress
%K muscarinic receptor
%K forced swimming
%K motility.
%U http://www.scielo.org.ve/scielo.php?script=sci_abstract&pid=S0798-02642009000200007&lng=en&nrm=iso&tlng=en